Pakistan has retained six uncapped players in its squad of 17 for Tuesday's first test against South Africa in Karachi.
Three rookie batsmen — Kamran Ghulam, Abdullah Shafique and Salman Ali Agha — will remain with the team, but the Pakistan Cricket Board said they will not be considered for selection.
The selectors had initially announced 20 players for the two-test series but trimmed the squad to 17 for the first test at the National Stadium on Sunday.
The second test will be played at Rawalpindi from Feb. 8 and will be followed by a three-match Twenty20 series at Lahore from Feb. 11-14.
The six uncapped players include opening batsman Imran Butt, middle-order batsman Saud Shakeel, spinners Nauman Ali and Sajid Khan and fast bowlers Haris Rauf and Tabish Khan.
"We know the home conditions and we have a chance here to play good cricket and win," Pakistan head coach Misbah-ul-Haq said during a virtual press conference on Sunday.
Pakistan has lost only two out of 44 test matches played at the National Stadium and one of those defeats came against South Africa when it last toured in 2007. England is the only other team that has won in Karachi when it beat Pakistan by six wickets in 2000.
Opening batsman Abid Ali, captain Babar Azam and Azhar Ali all scored centuries against Sri Lanka in the last test match here in December 2019 when Pakistan won by 263 runs.
Misbah said Pakistan has to rectify its shortcomings in fielding to beat South Africa. Without the injured Babar, Pakistan lost a recent test series 2-0 in New Zealand when it dropped more than half a dozen catches.
"Of course I am not satisfied (with the performance in New Zealand), we have to improve it," Misbah said.
The head coach and bowling coach Waqar Younis were summoned by the PCB's cricket committee earlier this month and gave the coaching staff another opportunity to turn around the fortunes of the team in the home series against South Africa.
Since Misbah and Waqar took over in 2019, Pakistan won home test series against Sri Lanka and also won a test match at Rawalpindi against Bangladesh. However, they have a poor touring record, losing test series in Australia, England and New Zealand.
But Misbah appeared unconcerned about whether his three-year contract with the PCB would continue if Pakistan struggles against South Africa.
"I have played cricket under pressure throughout my life," Misbah said.
"I know only one thing 'keep concentrating on what's in your end' and I am not thinking about what's going to happen (after the series against South Africa)."
Babar Azam (captain), Abid Ali, Imran Butt, Azhar Ali, Fawad Alam, Saud Shakeel, Faheem Ashraf, Mohammad Nawaz, Mohammad Rizwan, Sarfaraz Ahmed, Nauman Ali, Sajid Khan, Yasir Shah, Haris Rauf, Hasan Ali, Shaheen Afridi, Tabish Khan