State Council of Turkey is going to decide if the world heritage site Hagia Sophia in Istanbul can be converted into a mosque.
Built in the Sixth Century on the orders of Byzantine Emperor Justinian I, it was the world's largest cathedral for nearly 1,000 years, reports BBC.
The Unesco World Heritage site was turned into a mosque when the Ottoman Empire captured the city in 1453, but became a museum in the 1930s.
It may become a mosque again if the court approves the move on Thursday.
Turkey's President Recep Tayyip Erdogan called for the change during an election rally last year.
Islamists in Turkey have long called for it to be converted, but secular opposition members have opposed the move. The proposal has prompted international criticism, from religious and political leaders worldwide.
The head of the Eastern Orthodox Church has opposed the move, as has Greece - home to many millions of Orthodox followers.
Culture Minister Lina Mendoni has accused Turkey of reviving "fanatical nationalist and religious sentiment", insisting no change to a Unesco World Heritage site can take place without being approved by the body's own intergovernmental committee.
Unesco deputy director Ernesto Ottone Ramirez agreed that wider approval was needed, in an interview with Greek newspaper Ta Nea.
The UN body had written to Turkey about the proposal, but received no reply, he said.
What's the history?
The iconic, domed building sits in Istanbul's Fatih district, on the west bank of the Bosporus.
Justinian I ordered the massive construction built in 532, when the city - then known as Constantinople - was the capital of the Byzantine Empire, also known as the Eastern Roman Empire. Engineers brought materials from across the Mediterranean to build the colossal cathedral.
On completion in 537 it became the seat of the Orthodox patriarch of the capital. Byzantine imperial ceremonies such as coronations took place at the building.
The Hagia Sophia served as the home of the Eastern Orthodox Church for nearly 900 years, barring a brief period in the 13th Century when it was a Catholic cathedral under control of European invaders who ransacked and occupied Constantinople during the Fourth Crusade.
But in 1453, the Ottoman Empire under Sultan Mehmed II captured Constantinople and renamed the city Istanbul, finishing off the Byzantine Empire once and for all.
On entering the Hagia Sophia, Mehmed II insisted it be renovated and converted into a mosque. He attended the first Friday prayers in the building, days after it was ransacked by invading forces.
Ottoman architects removed or plastered over Orthodox symbols inside and added spires and minarets to the structure. Until the completion of Istanbul's Blue Mosque in 1616 the Hagia Sophia was the main mosque in the city, and its architecture inspired builders of the Blue Mosque and several others around the city and the world.
After the end of World War I in 1918, the Ottoman Empire was defeated and divided by the victorious Allies. Nationalist forces, however, rose up and created modern-day Turkey from the ashes of that empire.
The founder of Turkey and the secular republic's first president, Mustafa Kemal Ataturk, ordered the Hagia Sophia to be turned into a museum. Since reopening to the public in 1935 it has become one of Turkey's most visited tourist attractions.
Why does it matter?
Because of its 1,500-year history, the Hagia Sophia holds immense religious, spiritual and political significance for groups inside and outside Turkey.
Islamist groups and devout Muslims demand the building be turned back into a mosque, and have staged protests outside it, against a 1934 law that bars religious services at the site.
President Erdogan has echoed those calls. In a campaign speech ahead of local elections last year he said it had been a "very big mistake" to turn the Hagia Sophia into a museum, and he has since reportedly asked aides to examine how to convert the building.
The head of the Eastern Orthodox Church, known as the Ecumenical Patriarch of Constantinople, is still based in Istanbul. Patriarch Bartholomew It warned on Tuesday that the conversion of the building would "disappoint millions of Christians" and fracture two worlds.
US Secretary of State Mike Pompeo warned that any change in the Hagia Sophia's status would diminish its ability to "serve humanity as a much-needed bridge between those of differing faith traditions and cultures".
Last week US Ambassador at Large for International Religious Freedom Sam Brownback called on Turkey to leave the building as it was.
But Turkish foreign minister Mevlut Cavusoglu insisted that Athens had no say in the decision as the building was on Turkish territory.
"What we do in our country and with our property is up to us," he reportedly told on a Turkish local media.