Pakistan reported the number of confirmed cases had more than doubled for a second consecutive day, reaching 187.
Officials said the jump was largely due to errors in testing and quarantine of travellers who recently returned from Iran through a border crossing in Balochistan province.
"If the arrangements were better we could have saved these people from the virus," Saeed Ghani, a minister in the provincial Sindh government where many of the cases were detected, told a television channel on Monday night.
Pakistan postponed its flagship Pakistan Super League cricket tournament on Tuesday at the semi-final stage.
Authorities in India and the wider South Asian region have struggled to get travellers to self-isolate or stay quarantined in medical facilities that many view as poor and unhygienic.
At least 38 Afghans, who recently returned from Iran and were in isolation, escaped from a facility in western Afghanistan on Monday after breaking windows and attacking hospital staff.
At least one of them was confirmed to have the coronavirus. The country currently has 22 confirmed cases.
Separately, in Navi Mumbai, a suburb of India's financial hub, local media reported that 11 people, who had been isolated after returning from Dubai, also fled the hospital, forcing police to launch a manhunt.
Although South Asia has been relatively lightly hit by the coronavirus spread, authorities fear that measures used in China and South Korea would be hard to enforce in poor, crowded places that often lack adequate healthcare facilities.
With the overnight spike in Pakistan, the overall number of confirmed cases in South Asia is now approaching the 400 mark.
Sri Lanka, which is heavily reliant on tourism for foreign exchange, saw its currency hit a record low against the dollar on Tuesday. Pakistan's stock market continued to slide, a day after recording one of its biggest ever one-day declines.