Prescriptions for the anti-malarial drugs chloroquine and hydroxychloroquine skyrocketed in the US from February to March — a time when the drugs, though unproven, were touted as treatments for the coronavirus.
Researchers found the estimated number of hydroxychloroquine prescriptions increased 86.2 percent from February to March, from 367,346 to 683,999, and dispensed chloroquine prescriptions increased 158.6 percent, rising from 2,346 to 6,066 prescriptions.
Combining hydroxychloroquine and the antibiotic azithromycin had also been touted as a possible treatment for coronavirus infection. The analysis shows that the estimated number of patients receiving both drugs rose by 1,004 percent between February and March, from 8,885 to 101,681.
The data, published in a research letter Monday by the journal JAMA Internal Medicine, found prescription rates for chloroquine and hydroxychloroquine were stable from October 2019 through February 2020. The analysis only examined data through March.
The authors noted that the increased prescriptions might not all be attributed to Covid-19, as their data did not include for what purpose the drugs were prescribed. Still, they wrote that the sudden surge of hydroxychloroquine and chloroquine prescriptions may have affected availability for patients prescribed the drugs for uses approved by the US Food and Drug Administration, including for treating rheumatoid arthritis, lupus and malaria.
The FDA withdrew its emergency use authorization for hydroxychloroquine and chloroquine for Covid-19 on June 15.
Some researchers thought chloroquine and hydroxychloroquine might be able to fight coronavirus based on initial laboratory analyses, and President Trump became a cheerleader of the treatment, calling it "very encouraging" and "very powerful" and a "game-changer."
But in recent studies of Covid-19 patients, the drugs have largely not stacked up. A randomized clinical trial — considered the gold-standard for determining drug efficacy — was halted by the National Institutes of Health after data showed hydroxychloroquine provided no benefit to Covid-19 patients.
"While there was no harm, the study drug was very unlikely to be beneficial to hospitalized patients with Covid-19," the NIH said in a June 20 news release.