Australia doubles Pfizer vaccine order as clotting worries upend rollout

 Australia has doubled its order of the Pfizer Inc Covid-19 vaccine, Prime Minister Scott Morrison said on Friday, as the country raced to overhaul its inoculation plan over concerns about the risks of blood clots with the AstraZeneca Plc vaccine.

Until late Thursday, Australia based its vaccination programme largely on AstraZeneca shot, with an order for 50 million doses - enough for the required two shots for its entire 25 million population - to be made domestically by biopharma CSL Ltd.

But Australia has now joined a host of countries in restricting use of the vaccine due to clotting concerns. Local health authorities have changed their recommendation to say the country's nearly 12 million people aged under 50 should take the Pfizer product instead.

As a result Australia has doubled an earlier Pfizer order to 40 million shots, enough for four-fifths of the population, which would be delivered by the end of the year, Morrison said.

The policy change to Pfizer effectively ending plans to have the entire population vaccinated by the end of October.

"It is not a prohibition on the AstraZeneca vaccine," Morrison told reporters in Canberra after a national cabinet meeting to discuss the virus response.

"For those who are over 50, there is a strong encouragement to be taking this AstraZeneca vaccine."

Health Secretary Brendan Murphy called the policy change "highly precautionary" given the low rates of possible adverse effects associated with the AstraZeneca shot.

"I've had it, I'd have it again, I'd recommend it to any member of my family," Murphy said.

More than a dozen countries have at one time suspended use of the AstraZeneca vaccine, but most have resumed, with some, including France, the Netherlands and Germany, recommending a minimum age.

Australia's most populous state New South Wales, home to nearly a third of the population, said it was pausing the AstraZeneca rollout to update "informed consent" documents which notify patients of risks.

Before the updated Pfizer order was announced, AstraZeneca said in a statement that it respected the Australian decision and was working with regulators around the world "to understand the individual cases, epidemiology and possible mechanisms that could explain these extremely rare events".

CSL said it remained committed to meeting its contracted arrangements with Australia and AstraZeneca to make the vaccine "which remains critical for the protection of our most vulnerable populations".

'Eggs in one basket'

As well as the AstraZeneca and Pfizer contracts, Australia ordered 51 million doses of a vaccine being trialled by US pharmaceutical giant Novavax Inc, but local authorities say they do not expect to approve the product until late 2021.

Australia also embarked on a home-grown option - as opposed to local manufacture of AstraZeneca's offshore-developed product - with University of Queensland undertaking a trial of its own vaccine. That trial was aborted in December when the product was linked to false positives in HIV tests.

After saying Australia had 150 million vaccine doses on order, enough for several times the population, the government said in January that it planned to have four million vaccinated by the end of March, only to have 600,000 by that time.

"Australians won't forget who is responsible for failing to deliver on what are his own promises and his own commitments," opposition Labor leader Anthony Albanese told reporters on Friday.

"They should have listened to the expert advice that was given to the government, and indeed to all governments, about not placing all our eggs in one basket".

New Zealand Prime Minister Jacinda Ardern, who agreed this week to allow quarantine-free visits by travellers from neighbouring Australia, said the country was still assessing the AstraZeneca vaccine, without specifying whether the Australian decision would affect it.

The Pfizer vaccine is the only inoculation approved by New Zealand, which says it has ordered enough for its five million population.

Australia began vaccinations later than some other countries because of its low number of infections, which stand at just under 29,400, with 909 deaths, since the pandemic began.