Chiles have been used for therapeutic purposes for many years but researchers have found that risk of heart attack and stroke can be reduced by eating chilli peppers regularly.
The study was carried out in Italy, where chilli is a common ingredient, reports CNN.
It compared the risk of death among 23,000 people of whom some ate chilli and some did not.
Participants' health status and eating habits were monitored over eight years, and researchers found that the risk of dying from a heart attack was 40% lower among those eating chilli peppers at least four times per week.
Death from stroke was more than halved, according to results published Monday in the Journal of the American College of Cardiology.
"An interesting fact is that protection from mortality risk was independent of the type of diet people followed," said study lead author Marialaura Bonaccio, an epidemiologist at the Mediterranean Neurological Institute (Neuromed).
"In other words, someone can follow the healthy Mediterranean diet, someone else can eat less healthily, but for all of them, chilli pepper has a protective effect," she said.
The research uses data from the Moli-Sani study, which has around 25,000 participants in the Molise region of southern Italy.
Licia Iacoviello, director of the department of epidemiology and prevention at Neuromed and a professor at the University of Insubria in Varese, explained that the beneficial properties of chilli had been passed down through Italian food culture.
"And now, as already observed in China and in the United States, we know that the various plants of the capsicum species, although consumed in different ways throughout the world, can exert a protective action towards our health," said Iacoviello.
The team now plans to investigate the biochemical mechanisms that make chilli good for our health.
External experts praised the study while pointing out some limitations.
Duane Mellor, a registered dietitian and senior teaching fellow at Aston Medical School in the UK said the paper is "interesting" but "does not show a causal link" between chilli consumption and health benefits.
Mellor said the positive effect of chilli consumption observed in the study could be attributed to how the peppers are used in an overall diet.
"It is plausible people who use chillies, as the data suggests also used more herbs and spices, and as such likely to be eating more fresh foods including vegetables," he said.
"So, although chillies can be a tasty addition to our recipes and meals, any direct effect is likely to be small and it is more likely that it makes eating other healthy foods more pleasurable."
Ian Johnson, a nutrition researcher at Quadram Institute Bioscience in Norwich, England, praised the "high-quality observational study" for its "robust methods."
However, he also pointed out that no mechanism for the protective effect was identified, nor did scientists find that eating more chilli provided additional health benefits.
"This type of relationship suggests that chillies may be just a marker for some other dietary or lifestyle factor that hasn't been accounted for but, to be fair, this kind of uncertainty is usually present in epidemiological studies, and the authors do acknowledge this," said Johnson.