Fast bowler Mohammed Shami picked up a five-wicket haul while left-arm spinner Ravindra Jadeja took four in South Africa's second innings to hand India a convincing 203-run victory in the opening test at Visakhapatnam on Sunday.
Chasing an improbable 395 for victory, the tourists were all out for 191 in the second session after resuming on 11 for one on the fifth and final day.
Shami returned figures of 5-35 while Jadeja picked up 4-87 with tailender Dane Piedt top-scoring for the touring side with 56, his maiden test half-century.
It was the third straight win in as many matches for top-ranked side India in the World Test Championships. The hosts took a 1-0 lead in the three-match series with the second test starting at Pune from Thursday.