The coronavirus outbreak claimed its first life in Hong Kong on Tuesday, compounding the international financial centre's problems after anti-government protests, and Macau, the world's biggest gambling playground, urged casinos to shut their doors.
The victim in Hong Kong was a 39-year-old man with an underlying illness who had visited China's Wuhan city, the epicentre of the outbreak now under virtual quarantine.
It was the second death from the new coronavirus outside mainland China. A man died in the Philippines last week after visiting Wuhan, the first virus-related overseas fatality.
State TV late on Tuesday reported 3,156 new cases in China's central Hubei province, as well as 65 new deaths, bringing the total to 479 deaths in Hubei. Wuhan is the capital of Hubei.
Thousands of medical workers in Hong Kong, a semi-autonomous region of China, held a second day of strikes to press for complete closure of borders with the mainland after three checkpoints were left open.
"We're not threatening the government, we just want to prevent the outbreak," said a nurse taking part in the strike.
On the financial front, global and Chinese markets rose, with both Europe and metals enjoying their best sessions of the year after Shanghai's main market lost nearly $400 billion (£306.82 billion) the previous day.
But in the latest corporate hit, Hyundai Motor said it would gradually suspend production at South Korean factories because of supply chain disruptions.
Prior to the latest figures from Hubei, total infections in mainland China had climbed to 20,438. Nearly 200 cases have been reported across roughly two dozen countries, Hong Kong and Macau.
Macau, also a special administrative region of China lying across the Pearl River estuary from Hong Kong, said it had asked all casino operators to suspend operations for two weeks to help prevent the coronavirus spreading.
Macau's chief executive, Ho Iat Seng, made the announcement as the former Portuguese colony, whose glittering casinos draw hundreds of thousands of gamblers from across the globe, reported 10 confirmed cases of the virus and imposed tight restrictions on movements in and out of the territory.
Thailand's tally of infections jumped to 25, the highest outside China, while Singapore's rose to 24.
The World Health Organization (WHO) has declared the flu-like virus a global emergency, and experts say much is still unknown, including its mortality rate and transmission routes.
Such uncertainties have spurred strong measures by some countries, offending Beijing's communist government, which has called for calm, fact-based responses instead of scaremongering.
Australia sent hundreds of evacuees from Wuhan to an island in the Indian Ocean, while Japan confirmed about 10 cases of coronavirus among 3,700 passengers and crew aboard a cruise liner held in quarantine, TV Asahi said, citing the health ministry.
Hong Kong has confirmed 17 cases. The territory was badly hit by Severe Acute Respiratory Syndrome (SARS), a coronavirus that emerged from China in 2002, killed almost 800 people worldwide and cost the global economy an estimated $33 billion.
Chinese data suggests the new virus, while much more contagious, is significantly less lethal, although such numbers can evolve rapidly.
WHO director of global hazard preparedness Sylvie Briand said most who had died or suffered severe infections were people with underlying health conditions or the elderly.
"Not A Catastrophe"
Raising the prospect of another dispute as trade frictions were easing, Beijing on Monday accused the United States of spreading panic after it announced plans to block nearly all recent foreign visitors to China.
A handful of other nations have done the same.
Britain told its citizens to leave China if they could, and Russia set up a quarantine centre in remote Siberia, where there have been two cases, for Russians evacuated from China.
With the world's second biggest economy facing increasing isolation and disruption, some economists predict world output will shrink by 0.2 to 0.3 percentage points.
White House economic adviser Larry Kudlow played down the potential impact on the United States, but said on Tuesday that China's coronavirus would delay a surge in US exports to China expected from the Phase 1 trade deal that was to take effect later this month.
MSCI's main world index rose 0.5%, led by the biggest leap in commodity-focused stocks in more than three months. "Investors are tentatively going back into risk," said MUFG strategist Lee Hardman.
Many airlines have stopped flights to parts of China.
A flight from Toronto to Jamaica was forced back when a Canadian man falsely announced to passengers that he had the coronavirus - and took a selfie. He was arrested.