Closely watched arthritis drug disappoints in Covid-19 trial
Skip to main content
  • Home
  • Economy
    • Aviation
    • Bazaar
    • Budget
    • Industry
    • NBR
    • RMG
    • Corporates
  • Stocks
  • Analysis
  • World+Biz
  • Sports
  • Features
    • Book Review
    • Brands
    • Earth
    • Explorer
    • Fact Check
    • Family
    • Food
    • Game Reviews
    • Good Practices
    • Habitat
    • Humour
    • In Focus
    • Luxury
    • Mode
    • Panorama
    • Pursuit
    • Wealth
    • Wellbeing
    • Wheels
  • Epaper
  • More
    • Subscribe
    • Videos
    • Thoughts
    • Splash
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • COVID-19
    • Games
    • Long Read
    • Interviews
    • Offbeat
    • Podcast
    • Quiz
    • Tech
    • Trial By Trivia
    • Magazine
  • বাংলা
The Business Standard

Saturday
February 04, 2023

Sign In
Subscribe
  • Home
  • Economy
    • Aviation
    • Bazaar
    • Budget
    • Industry
    • NBR
    • RMG
    • Corporates
  • Stocks
  • Analysis
  • World+Biz
  • Sports
  • Features
    • Book Review
    • Brands
    • Earth
    • Explorer
    • Fact Check
    • Family
    • Food
    • Game Reviews
    • Good Practices
    • Habitat
    • Humour
    • In Focus
    • Luxury
    • Mode
    • Panorama
    • Pursuit
    • Wealth
    • Wellbeing
    • Wheels
  • Epaper
  • More
    • Subscribe
    • Videos
    • Thoughts
    • Splash
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • COVID-19
    • Games
    • Long Read
    • Interviews
    • Offbeat
    • Podcast
    • Quiz
    • Tech
    • Trial By Trivia
    • Magazine
  • বাংলা
SATURDAY, FEBRUARY 04, 2023
Closely watched arthritis drug disappoints in Covid-19 trial

Coronavirus chronicle

BSS/AFP
28 April, 2020, 11:20 am
Last modified: 28 April, 2020, 11:33 am

Related News

  • Hong Kong says 'hello' to woo back visitors after Covid
  • US to end Covid-19 emergency declarations on 11 May
  • Covid remains a public health emergency, says WHO
  • Holiday trips within China surge after lifting of Covid curbs
  • India launches world’s 1st intranasal Covid vaccine

Closely watched arthritis drug disappoints in Covid-19 trial

An early small study in China had appeared promising, but the drug showed no benefit over a placebo in a larger US study of 276 patients with “severe” disease

BSS/AFP
28 April, 2020, 11:20 am
Last modified: 28 April, 2020, 11:33 am
Hydroxychloroquine Sulfate medication. Photo: John Phillips/Getty Images via Bloomberg
Hydroxychloroquine Sulfate medication. Photo: John Phillips/Getty Images via Bloomberg

An arthritis drug that was being closely watched for its potential use against Covid-19 has delivered disappointing results in clinical trials, its makers said Monday.

Kevzara, which is made by Regeneron and Sanofi, does not attack the novel coronavirus but instead inhibits an abnormal immune response called a "cytokine storm" that causes the lungs of the sickest patients to become inflamed, leaving them fighting for their lives on ventilators.

An early small study in China had appeared promising, but the drug showed no benefit over a placebo in a larger US study of 276 patients with "severe" disease — that is to say, those requiring oxygen but not ventilators.

There was, however, a ray of hope for those who were "critical," defined as needing mechanical ventilation or high-flow oxygenation. In this group, 44 were on a placebo, 94 were given a low dose and 88 were given a high dose.

Fifty-five percent of patients on the placebo died by the end of the study period, compared with 46 percent on the lower dose and 32 percent on the high dose.

The trial will continue among this critical group.

"We await results of the ongoing Phase 3 trial to learn more about Covid-19, and better understand whether some patients may benefit from Kevzara treatment," said George Yancopoulos, Regeneron's president and co-founder.

The company is separately developing an antibody cocktail that will directly target the virus and that it hopes to advance into human trials by June.

These antibodies are being acquired by infecting mice that have had their immune systems genetically modified to become human-like.

Regeneron has previously used this system to develop a treatment that proved effective against Ebola.

Top News

Arthritis drug / Coronavirus treatment / Coronavirus Drugs / fighting coronavirus / Coronavirus / COVID-19

Comments

While most comments will be posted if they are on-topic and not abusive, moderation decisions are subjective. Published comments are readers’ own views and The Business Standard does not endorse any of the readers’ comments.

Top Stories

  • Illustration: TBS
    Cash-strapped banks fail to maintain emergency cash
  • Is the IMF to blame for growing pressure on your wallet?
    Is the IMF to blame for growing pressure on your wallet?
  • Photo: Joynal Abedin Shishir/TBS
    BNP's anti-govt rally underway at Nayapaltan

MOST VIEWED

  • Tourists ride a tour bus in Hong Kong, China October 25, 2019. REUTERS/Ammar Awad
    Hong Kong says 'hello' to woo back visitors after Covid
  • People wearing face masks following the coronavirus disease (Covid-19) outbreak are seen at Beijing Daxing International Airport in Beijing, China July 23, 2020. Photo:Reuters
    Pandemic to paradise: Chinese tourists return to Bali after three years
  • People walk outside wearing masks during the coronavirus disease (COVID-19) pandemic in the Harlem area of the Manhattan borough of New York City, New York, U.S., February 10, 2022. REUTERS/Carlo Allegri
    US to end Covid-19 emergency declarations on 11 May
  • A nurse prepares a shot for Jonathan Halter as the German embassy begins its roll out of BioNTech COVID-19 vaccines for German expatriates at a Beijing United Family hospital in Beijing, China January 5, 2023. REUTERS/Thomas Peter/File Photo
    Covid remains a public health emergency, says WHO
  • FIKE PHOTO: Medical staff moves a patient into a fever clinic at a hospital, as coronavirus disease (COVID-19) outbreaks continue in Shanghai, China, December 19, 2022. REUTERS/Aly Song
    China approves two domestically developed Covid drugs
  • People walk with their luggage at a railway station during the annual Spring Festival travel rush ahead of the Chinese Lunar New Year, as the coronavirus disease (COVID-19) outbreak continues, in Shanghai, China January 16, 2023. REUTERS/Aly Song
    Holiday trips within China surge after lifting of Covid curbs

Related News

  • Hong Kong says 'hello' to woo back visitors after Covid
  • US to end Covid-19 emergency declarations on 11 May
  • Covid remains a public health emergency, says WHO
  • Holiday trips within China surge after lifting of Covid curbs
  • India launches world’s 1st intranasal Covid vaccine

Features

Sketch: TBS

Say 'Salud' before your salad main course

5h | Food
With only one government run specialised cancer hospital in the capital — the National Institute Of Cancer Research and Hospital (NICRH) in Mohakhali — patients have no option but to resort to private hospitals. Photo: Noor A Alam.

Cancer care: Medical treatment and beyond

6h | Panorama
Andy Mukherjee. Sketch: TBS

What makes India's billionaires' support special for Adani

1d | Panorama
Photo: Rejaul Hafiz Rahi

A jackal farewell

1d | Earth

More Videos from TBS

Concord launches new plant to produce environment friendly bricks

Concord launches new plant to produce environment friendly bricks

2h | TBS Stories
How Asif Khan would invest his fresh funds right now

How Asif Khan would invest his fresh funds right now

3h | TBS Markets
A proper price formula can help investors to plan big

A proper price formula can help investors to plan big

1d | TBS Round Table
Rumors about Sarika that everyone thinks are true

Rumors about Sarika that everyone thinks are true

1d | TBS Entertainment

Most Read

1
Leepu realised his love for cars from a young age and for the last 40 years, he has transformed, designed and customised hundreds of cars. Photo: Collected
Panorama

'I am not crazy about cars anymore': Nizamuddin Awlia Leepu

2
Photo: Collected
Energy

8 Ctg power plants out of production

3
The International Monetary Fund (IMF) logo is seen outside the headquarters building in Washington, U.S., September 4, 2018. REUTERS/Yuri Gripas/File Photo
Economy

IMF approves $4.7 billion loan for Bangladesh, calls for ambitious reforms

4
Fund cut as Dhaka's fast-track transit projects on slow spending lane
Infrastructure

Fund cut as Dhaka's fast-track transit projects on slow spending lane

5
Photo: Collected
Court

Japanese mother gets guardianship of daughters, free to leave country

6
Belal Ahmed new acting chairman of SIBL
Banking

Belal Ahmed new acting chairman of SIBL

EMAIL US
[email protected]
FOLLOW US
WHATSAPP
+880 1847416158
The Business Standard
  • About Us
  • Contact us
  • Sitemap
  • Privacy Policy
  • Comment Policy
Copyright © 2023
The Business Standard All rights reserved
Technical Partner: RSI Lab

Contact Us

The Business Standard

Main Office -4/A, Eskaton Garden, Dhaka- 1000

Phone: +8801847 416158 - 59

Send Opinion articles to - [email protected]

For advertisement- [email protected]