United Hospital has successfully applied the chrono modulated chemotherapy course on a patient with advanced colon cancer for the first time in the country.
Chrono modulated chemotherapy is a time-controlled chemotherapy course, said a press statement issued by the hospital on Saturday.
There are few specific clock related genes in human brainstems that control our time-dependent biological functions, including sleeping and eating patterns, heart rate, body temperature and some others.
Similarly, cancer cells also divide and take rest at different times of a given day.
In chrono modulated chemotherapy, the chemotherapy drugs are administered at the specific time when cancer cells become activefor making the cells more vulnerable to cell death.
Dr Ashim Kumar Sen Gupta, consultant for oncology at the United Hospital, said, this special type time-controlled chemotherapy administration improves treatment tolerance, and also can improve treatment response and survival.
This can be given to patients who previously needed to discontinue a chemotherapy protocol – either because it was ineffective or it was too debilitating for the patient to tolerate.
In metastatic colon canceror advanced metastatic ovarian cancer, studies show that administering chemotherapy at the optimal time can halve toxicity and double treatment response, the press statement said.